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Variations in sex steroid priming for growth hormone stimulation testing in UK
  1. Carley Frerichs1,
  2. Lorna Raymond2,
  3. Senthil Senniappan1
  1. 1Department of Paediatric Endocrinology, Alder Hey Children's Hospital, Liverpool, UK
  2. 2University of Liverpool, Liverpool, UK
  1. Correspondence to Dr Senthil Senniappan, Department of Paediatric Endocrinology, Alder Hey Children's Hospital NHS Trust, Liverpool, UK; senthilkss{at}

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Identifying growth hormone deficiency (GHD) can be a diagnostic challenge. In clinical practice, it can be difficult to differentiate among GHD, idiopathic short stature or constitutional delay of growth and puberty. A combination of auxological data, insulin-like growth factor 1 activity, neuroimaging and detailed clinical history is used alongside growth hormone stimulation tests (GHSTs).

There is variation in UK practice on how children are tested for GHD.1 GH treatment is expensive as well as burdensome to the patient.

It is well known that sex steroids augment the GH response …

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