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Juvenile idiopathic arthritis (JIA) represents the most common chronic inflammatory musculoskeletal disease in children. It is characterised by the onset of inflammatory arthritis prior to the 16th birthday and can follow many patterns ranging from oligoarthritis to polyarthritis to the most severe subtype, systemic juvenile idiopathic arthritis (sJIA).1 The disease course can be variable with many children achieving drug-free remission. It is estimated that at least 60% of children will require systemic drug therapy with methotrexate, primarily but not limited to those with polyarthritis and systemic arthritis, and of these at least 20% will go on to require additional treatment with a biologic.2
Mortality rates in JIA are reported to be increased when compared with the general population, but likely vary by subtype and disease severity.3–5 …
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