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Are neutrophils the culprit in CF lung damage?

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The progressive deterioration in lung function seen in cystic fibrosis (CF) has always been thought to be due to the primary effects of the gene mutation on respiratory mucosal secretions, compounded by bacterial infections. Although we knew that inflammation per se plays a part, exuberant inflammatory processes were thought to be a result of chronic infection rather than a primary effect of the mutation on inflammatory cells: until now. Researchers from Edinburgh conducted a series of experiments that implicate neutrophils, and more specifically neutrophil extracellular traps (NETs), …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.