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Lack of effect of azithromycin on QT interval in children: a cohort study
  1. David Espadas,
  2. Silvia Castillo,
  3. Marcela Moreno,
  4. Amparo Escribano
  1. Pediatric Pulmonology Unit, University Clinical Hospital of Valencia, University of Valencia, Valencia, Spain
  1. Correspondence to Professor Amparo Escribano, Unidad de Neumología Infantil, Hospital Clínico Universitario de Valencia. Av. Blasco Ibáñez, 17., Valencia 46010, España; aescribano{at}separ.es

https://doi.org/10.1136/archdischild-2016-310956

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    Macrolides are a group of antimicrobial drugs used widely, being well known for their adverse cardiac effects. Erythromycin and clarithromycin are most commonly associated with these conditions. In recent years, azithromycin (AZM) has been assessed because of its possible relation to arrhythmias (mainly QT interval prolongation) and risk of cardiovascular death.1 The pharmacodynamics of these effects is complex and the occurrence of cardiovascular death is unpredictable.2 However, all published manuscripts on the cardiac effects of AZM to date are cases in adults or …

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    Footnotes

    • Competing interests None declared.

    • Patient consent Parental/guardian consent obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.