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What can we do with imperfect ‘gold standards’, for example the situation of serious infection in children. We know someone has got a serious infection because they (a) look poorly and (b) have a blood, urine or CSF culture that grows a Nasty Bug That Fits The Picture.
We also know that not all bugs that cause problems are grown in culture bottles.
So, how do we evaluate a new technology, such as …
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