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  1. David Terry1,
  2. Ebraheem Junaid1,
  3. Fiona Reynolds1,
  4. Anthony Sinclair1,
  5. Neil Bugg1,
  6. Alex Terry1,
  7. Josh Terry1,
  8. Akhmed Hussain1,
  9. John Caffrey1,
  10. Alice Burridge2
  1. 1 Birmingham Children's Hospital NHS FT
  2. 2 Aston University


Aim To determine a system of information inputs and checks to support the development of an electronic paediatric drug database (DD). The DD is designed as a clinical support tool to aid paediatric drug dose selection within both prescribing and pharmacist clinical-screening. The standardised DD system may be useful as a reference tool within electronic prescribing systems.

Method A multi-disciplinary team was appointed to identify the stages required to build, populate and check the DD. The team included senior and junior medical staff, senior and junior pharmacists, pharmacy technicians, data analyst/database engineer, nursing staff and project manager. An iterative process of design, build, test and refine was used until governance oversight concluded that the system was robust and fit for purpose. The DD was built in Microsoft (MS) Access 2007, and allows multi-user entry of information and checking/verification of details at five levels prior to release for clinical use. Information arbitration is provided by a senior oversight team consisting of the Deputy Chief Medical Officer, Chair of Drugs and Therapeutics Committee and Director of the Academic Practice Unit (a clinical pharmacist).

Results Common data sources used in clinical practice were identified as suitable for information harvesting. These included: standard reference texts e.g. BNFc; Guy's and St Thomas', King's College and University Lewisham Hospital Paediatric Formulary; clinical guidelines–both national and local; relevant clinical alerts etc.

The DD system is based on five core data fields: Drug, Indication, Route, Age, and Dose; known as a DIRAD. Each DIRAD is unique with processes in place to ensure they are not duplicated. Input of a draft DIRAD occurs at level 1 (L1), which is the lowest level in the five level process. DIRADs pass through each level progressing from L1 to L5. DIRADs are considered by each of the higher levels (L2 – L5) in turn, which are: L2 – general clinical pharmacist; L3 – specialist clinical pharmacist; L4 – experienced medical staff; L5 – clinical specialty. The DIRAD may only be accepted or rejected at L2 to L5. Any requests for modification requires the DIRAD to return to L1. In this manner DIRADs are only created or modified at L1. Passage through the system to final approval at L5 requires acceptance of the DIRAD at each and every level in the process. To date (July 2014) over 3,000 DIRADs have been entered into the system representing 765 drug entities. Reference to relevant dm+d codes are allowed within the DD structure. Migration of the system to a Structured Query Language (SQL)) Server platform is planned.

Conclusion The developed five stage process has been successfully used to capture and validate clinical information suitable to support electronic prescribing of medicines for paediatrics. The core data structure is based on unique DIRADs: Drug; Indication; Route; Age and Dose. The database is a suitable aid to identify doses of drugs within paediatrics and is in a standardised format which may be suitable for incorporation into electronic prescribing systems.

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