Article Text

Download PDFPDF
Probiotic supplementation in children with autism spectrum disorder
  1. Ravisha Srinivasjois1,
  2. Shripada Rao2,
  3. Sanjay Patole3
  1. 1Department of Neonatology and Paediatrics, Joondalup Health Campus, Perth, Western Australia, Australia
  2. 2Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women, Perth, Western Australia, Australia
  3. 3Department of Neonatal Paediatrics, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
  1. Correspondence to Dr Ravisha Srinivasjois, Department of Paediatrics, Joondalup Health Campus, Suite 204, Specialist Medical Centre, Perth 6027, Australia; srinivasjoisr{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


A mother of a 4 year old with autism spectrum disorder (ASD) attends the paediatric outpatient clinic. Her son has significant behavioural difficulties, tantrums that are difficult to control, an obsession with spinning wheels and sensory difficulties. She has heard and read about the advantages of probiotic supplementation (PS) in ASD. She wants to know if her son should be given probiotics to improve his behaviour. You wonder if there is any evidence that regular PS improve behaviour in children with ASD.

Structured clinical question: In children with proven ASD (patient), does supplementation with any probiotic microorganism/s (intervention) compared with placebo/none (comparator) improve behaviour (outcome) in the short term?

Search strategy and outcome—secondary sources: The Cochrane Central Register of Controlled Trials (CENTRAL, the Cochrane library, Issue 2, 2012) was searched in …

View Full Text


  • Contributors RS and SR searched literature and wrote the initial manuscript. SP reviewed the evidence and edited the manuscript. All the authors had equal contribution in the manuscript.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Linked Articles