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Physical and neurodevelopmental outcomes in children with single-ventricle circulation
  1. Joseph Davidson1,
  2. Paul Gringras2,
  3. Charlie Fairhurst2,
  4. John Simpson3
  1. Correspondence to Professor John Simpson, Evelina London Children's Hospital, Guy's and St Thomas’ NHS Foundation Trust, London SE1 7EH, UK; john.simpson{at}


Objective To investigate longer-term physical and neurodevelopmental outcomes of patients with hypoplastic left heart syndrome (HLHS) compared with other patients with functionally single-ventricle circulation surviving beyond the age of 10 years.

Design A retrospective, observational study from a UK tertiary centre for paediatric cardiology.

Results 58 patients with HLHS and 44 non-HLHS patients with single-ventricle physiology were included. Subjective reduction in exercise tolerance was reported in 72% (95% CI 61% to 84%) of patients with HLHS and 45% (31% to 60%) non-HLHS patients. Compared with non-HLHS patients, educational concerns were reported more frequently in patients with HLHS, 41% (29% to 54%) vs 23% (10% to 35%), as was a diagnosis of a behaviour disorder (autism or attention deficit hyperactivity disorder) 12% (4% to 21%) vs 0%, and referral to other specialist services 67% (55% to 79%) vs 48% (33% to 63%).

Conclusions Within a group of young people with complex congenital heart disease, those with HLHS are likely to have worse physical, psychological and educational outcomes.

  • Neurodevelopment
  • Cardiology
  • Cardiac Surgery
  • Patient perspective
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