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Lymphadenopathy in children is a common presentation in primary care. It is often associated with heightened parental anxiety due to its association with cancer, although is often explained by self-limiting viral infections.1 The diagnostic challenge for the general practitioner (GP) is to determine which children have high-risk features of suspected cancer, warranting urgent referral to a paediatric specialist, from those with benign illnesses. The National Institute for Health and Care Excellence (NICE) referral guideline for suspected cancer provides access to an experienced paediatrician within 2 weeks.2 Evidence published in this journal reports that the yield of cancer diagnoses for children and young people referred via this …
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