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Multiple endocrine neoplasia syndromes 1 and 2: manifestations and management in childhood and adolescence
  1. D Giri1,
  2. V McKay2,
  3. A Weber2,
  4. JC Blair1
  1. 1Department of Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
  2. 2Department of Medical Genetics, Liverpool Women's Hospital, Liverpool, UK
  1. Correspondence to Dr JC Blair, Consultant Endocrinologist, Alder Hey Children's NHS Foundation Trust, Liverpool L12 2AP, UK; jo.blair{at}


The identification of the genetic causes of the multiple endocrine neoplasia (MEN) syndromes 1 and 2, and associated genotype–phenotype relationships, has revolutionised the clinical care of affected patients. A genetic diagnosis can be made during infancy and careful clinical surveillance, coupled with early intervention, has the potential to improve both morbidity and mortality. These developments have seen the management of patients with MEN move into the arena of paediatric medicine. In this review article, we consider the genetic causes of MEN together with the clinical manifestations and management of these syndromes.

  • Endocrinology
  • Genetics
  • Oncology
  • Screening

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