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Inter-individual variation in midazolam clearance in children
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  • Published on:
    Developmental influences on the pharmacokinetics and pharmacodynamics of midazolam

    I have read with great interest the systematic review to determine the extent of inter-individual variation in clearance of midazolam in children and to establish which factors are responsible for this variation (1). The authors found that the coefficient of clearance in plasma was greater in critically ill patients than non-critically ill patients. Furthermore, there is also a large inter-individual variation in midazola...

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    Conflict of Interest:
    None declared.