Background Mycoplasma pneumonia (MP) infections are often asymptomatic but can involve multiple organ systems. Secondary skin reactions are common, although few patients infected develop Stevens Johnson syndrome (SJS).

Results We describe 2 cases of Mycoplasma pneumoniae chest infection associated with Stevens Johnson syndrome. The two patients had prodromal symptoms of an upper respiratory tract infection before the onset of the eruption. The patients had extensive epidermal bullous vesicles, oropharyngeal and genital ulceration, injected conjunctivae and sclera and swollen lips with flaccid bullae. The mycoplasma IgG and IgM titers returned positive, and blood cultures and other titers were negative. They were successfully treated with macrolides and glucocorticoids.

Conclusion Although the clinical course may be severe and prolonged, the prognosis is uniformly good with complete recovery.