A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane
integrity. As a consequence, multiple death-promoting factors residing in the mitochondrial …

Purpose: We provide updated, clinically useful recommendations for treating children with
monosymptomatic nocturnal enuresis. Materials and Methods: Evidence was gathered from …

Aim The impact of the original International Children's Continence Society (ICCS)
terminology document on lower urinary tract (LUT) function resulted in the global …

Candida albicans is implicated in many biomaterial-related infections. Typically, these
infections are associated with biofilm formation. Cells in biofilms display phenotypic traits …

Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-
binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is …

Autophagy and apoptosis are two important and interconnected stress-response
mechanisms. However, the molecular interplay between these two pathways is not fully …

Purpose: We updated the terminology in the field of pediatric lower urinary tract function.
Materials and Methods: Discussions were held of the board of the International Children's …

The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its
activation are enigmatic. In this study, we show that loss of FADD or caspase-8 in a RIP3 …

Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the
cysteine protease caspase 1 have long been sought as a therapeutic because mice lacking …

Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1–2% of the world's
population and is characterized by widespread joint inflammation. Interleukin-1 is an …