Mechanisms of growth impairment in pediatric Crohn's disease
TD Walters, AM Griffiths - Nature reviews Gastroenterology & …, 2009 - nature.com
Crohn's disease manifests during childhood or adolescence in up to 25% of patients. The
potential for linear growth impairment as a complication of chronic intestinal inflammation is …
potential for linear growth impairment as a complication of chronic intestinal inflammation is …
[HTML][HTML] Predicting outcomes in pediatric crohn's disease for management optimization: systematic review and consensus statements from the pediatric inflammatory …
A Ricciuto, M Aardoom, E Orlanski-Meyer, D Navon… - Gastroenterology, 2021 - Elsevier
Background & Aims A better understanding of prognostic factors within the heterogeneous
spectrum of pediatric Crohn's disease (CD) should improve patient management and reduce …
spectrum of pediatric Crohn's disease (CD) should improve patient management and reduce …
Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study
D Turner, AR Otley, D Mack, J Hyams, J De Bruijne… - Gastroenterology, 2007 - Elsevier
Background & Aims: Colonoscopic appearance, the primary measure of disease activity in
adult ulcerative colitis, is less acceptable to children. Our aim was to develop a noninvasive …
adult ulcerative colitis, is less acceptable to children. Our aim was to develop a noninvasive …
Common variants at five new loci associated with early-onset inflammatory bowel disease
M Imielinski, RN Baldassano, A Griffiths, RK Russell… - Nature …, 2009 - nature.com
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …
causes of morbidity in children and young adults in the western world. Here we report the …
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study
S Kugathasan, LA Denson, TD Walters, MO Kim… - The Lancet, 2017 - thelancet.com
Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …
[HTML][HTML] Predicting outcomes in pediatric ulcerative colitis for management optimization: systematic review and consensus statements from the pediatric inflammatory …
E Orlanski-Meyer, M Aardoom, A Ricciuto, D Navon… - Gastroenterology, 2021 - Elsevier
Background & Aims A better understanding of prognostic factors in ulcerative colitis (UC)
could improve patient management and reduce complications. We aimed to identify …
could improve patient management and reduce complications. We aimed to identify …
[HTML][HTML] Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature
Y Haberman, TL Tickle, PJ Dexheimer… - The Journal of …, 2014 - Am Soc Clin Investig
Interactions between the host and gut microbial community likely contribute to Crohn
disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of …
disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of …
[HTML][HTML] Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Y Haberman, R Karns, PJ Dexheimer… - Nature …, 2019 - nature.com
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis
(UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …
(UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …
Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn's disease
TD Walters, MO Kim, LA Denson, AM Griffiths… - Gastroenterology, 2014 - Elsevier
Background & Aims Standard therapy for children newly diagnosed with Crohn's disease
(CD) includes early administration of immunomodulators after initial treatment with …
(CD) includes early administration of immunomodulators after initial treatment with …
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
CJ Moran, TD Walters, CH Guo… - Inflammatory bowel …, 2013 - academic.oup.com
Background Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel
disease (IBD) candidate genes as IL-10 restricts intestinal inflammation, IL-10 …
disease (IBD) candidate genes as IL-10 restricts intestinal inflammation, IL-10 …