[HTML][HTML] Criteria for pediatric sepsis—a systematic review and meta-analysis by the pediatric sepsis definition taskforce
Objective: To determine the associations of demographic, clinical, laboratory, organ
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …
[HTML][HTML] Acute bacterial meningitis in infants and children: epidemiology and management
S Agrawal, S Nadel - Pediatric Drugs, 2011 - Springer
Acute bacterial meningitis (ABM) continues to be associated with high mortality and
morbidity, despite advances in antimicrobial therapy. The causative organism varies with …
morbidity, despite advances in antimicrobial therapy. The causative organism varies with …
[HTML][HTML] Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …
(including infants, school-aged children, and adolescents) with septic shock and other …
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine
J Brierley, JA Carcillo, K Choong, T Cornell… - Critical care …, 2009 - journals.lww.com
Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …
Treatment of meningococcal disease
S Nadel, J Carcillo - Handbook of Meningococcal Disease Management, 2016 - Springer
Treatment of meningococcal disease Page 1 Chapter 6 Treatment of meningococcal disease
Simon Nadel, Joseph Carcillo Introduction Prompt recognition of meningococcal infection and …
Simon Nadel, Joseph Carcillo Introduction Prompt recognition of meningococcal infection and …
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial
Summary Background Drotrecogin alfa (activated)(DrotAA) is used for the treatment of adults
with severe sepsis who have a high risk of dying. A phase 1b open-label study has indicated …
with severe sepsis who have a high risk of dying. A phase 1b open-label study has indicated …
Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock
N Pathan, CA Hemingway, AA Alizadeh, AC Stephens… - The Lancet, 2004 - thelancet.com
Background Myocardial failure has a central role in the complex pathophysiology of septic
shock and contributes to organ failure and death. During the sepsis-induced inflammatory …
shock and contributes to organ failure and death. During the sepsis-induced inflammatory …
Variation in the tumor necrosis factor-α gene promoter region may be associated with death from meningococcal disease
S Nadel, MJ Newport, R Booy… - Journal of Infectious …, 1996 - academic.oup.com
Tumor necrosis factor-a (TNF-α) plays a central role in the pathophysiology of sepsis. Levels
of TNF-a are directly correlated with severity in meningococcal disease (MD). A …
of TNF-a are directly correlated with severity in meningococcal disease (MD). A …
Psychiatric outcome following paediatric intensive care unit (PICU) admission: a cohort study
G Rees, J Gledhill, ME Garralda, S Nadel - Intensive care medicine, 2004 - Springer
Objective To determine whether paediatric intensive care unit (PICU) admission is
associated with greater psychiatric morbidity in children and parents as compared with …
associated with greater psychiatric morbidity in children and parents as compared with …
Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit
Objective: To audit current UK practice of the management of severe sepsis in children
against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life …
against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life …