[HTML][HTML] Criteria for pediatric sepsis—a systematic review and meta-analysis by the pediatric sepsis definition taskforce

K Menon, LJ Schlapbach, S Akech, A Argent… - Critical care …, 2022 - journals.lww.com
Objective: To determine the associations of demographic, clinical, laboratory, organ
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …

[HTML][HTML] Acute bacterial meningitis in infants and children: epidemiology and management

S Agrawal, S Nadel - Pediatric Drugs, 2011 - Springer
Acute bacterial meningitis (ABM) continues to be associated with high mortality and
morbidity, despite advances in antimicrobial therapy. The causative organism varies with …

[HTML][HTML] Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

SL Weiss, MJ Peters, W Alhazzani, MSD Agus… - Intensive care …, 2020 - Springer
Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine

J Brierley, JA Carcillo, K Choong, T Cornell… - Critical care …, 2009 - journals.lww.com
Background: The Institute of Medicine calls for the use of clinical guidelines and practice
parameters to promote “best practices” and to improve patient outcomes. Objective: 2007 …

Treatment of meningococcal disease

S Nadel, J Carcillo - Handbook of Meningococcal Disease Management, 2016 - Springer
Treatment of meningococcal disease Page 1 Chapter 6 Treatment of meningococcal disease
Simon Nadel, Joseph Carcillo Introduction Prompt recognition of meningococcal infection and …

Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial

S Nadel, B Goldstein, MD Williams, H Dalton, M Peters… - The Lancet, 2007 - thelancet.com
Summary Background Drotrecogin alfa (activated)(DrotAA) is used for the treatment of adults
with severe sepsis who have a high risk of dying. A phase 1b open-label study has indicated …

Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock

N Pathan, CA Hemingway, AA Alizadeh, AC Stephens… - The Lancet, 2004 - thelancet.com
Background Myocardial failure has a central role in the complex pathophysiology of septic
shock and contributes to organ failure and death. During the sepsis-induced inflammatory …

Variation in the tumor necrosis factor-α gene promoter region may be associated with death from meningococcal disease

S Nadel, MJ Newport, R Booy… - Journal of Infectious …, 1996 - academic.oup.com
Tumor necrosis factor-a (TNF-α) plays a central role in the pathophysiology of sepsis. Levels
of TNF-a are directly correlated with severity in meningococcal disease (MD). A …

Psychiatric outcome following paediatric intensive care unit (PICU) admission: a cohort study

G Rees, J Gledhill, ME Garralda, S Nadel - Intensive care medicine, 2004 - Springer
Objective To determine whether paediatric intensive care unit (PICU) admission is
associated with greater psychiatric morbidity in children and parents as compared with …

Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit

DP Inwald, RC Tasker, MJ Peters… - Archives of disease in …, 2009 - adc.bmj.com
Objective: To audit current UK practice of the management of severe sepsis in children
against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life …