User profiles for "author:Senthil Senniappan"

Dr Senthil Senniappan

Verified email at doctors.org.uk
Cited by 1692

Hyperinsulinaemic hypoglycaemia: genetic mechanisms, diagnosis and management

S Senniappan, B Shanti, C James… - Journal of inherited …, 2012 - Springer
Hyperinsulinaemic hypoglycaemia (HH) is due to the unregulated secretion of insulin from
pancreatic β-cells. A rapid diagnosis and appropriate management of these patients is …

Childhood obesity: A review of current and future management options

LJ Apperley, J Blackburn… - Clinical …, 2022 - Wiley Online Library
Obesity is becoming increasingly prevalent in paediatric populations worldwide. In addition
to increasing prevalence, the severity of obesity is also continuing to rise. Taken together …

Congenital hyperinsulinism: recent updates on molecular mechanisms, diagnosis and management

D Giri, K Hawton, S Senniappan - Journal of Pediatric Endocrinology …, 2022 - degruyter.com
Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin
release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe …

[HTML][HTML] Sirolimus therapy in infants with severe hyperinsulinemic hypoglycemia

S Senniappan, S Alexandrescu… - … England Journal of …, 2014 - Mass Medical Soc
Hyperinsulinemic hypoglycemia is the most common cause of severe, persistent neonatal
hypoglycemia. The treatment of hyperinsulinemic hypoglycemia that is unresponsive to …

[HTML][HTML] Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism

VB Arya, S Senniappan, H Demirbilek, S Alam… - PloS one, 2014 - journals.plos.org
Context Congenital hyperinsulinism (CHI), the commonest cause of persistent
hypoglycaemia, has two main histological subtypes: diffuse and focal. Diffuse CHI, if …

Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities

D Giri, ML Vignola, A Gualtieri… - Human molecular …, 2017 - academic.oup.com
Congenital hypopituitarism (CH) is characterized by the deficiency of one or more pituitary
hormones and can present alone or in association with complex disorders. Congenital …

Diagnosing childhood-onset inborn errors of metabolism by next-generation sequencing

A Ghosh, H Schlecht, LE Heptinstall… - Archives of Disease in …, 2017 - adc.bmj.com
Background Inborn errors of metabolism (IEMs) underlie a substantial proportion of
paediatric disease burden but their genetic diagnosis can be challenging using the …

[HTML][HTML] Treating vitamin D deficiency in children with type I diabetes could improve their glycaemic control

D Giri, D Pintus, G Burnside, A Ghatak, F Mehta… - BMC research …, 2017 - Springer
Background and aims The relationship between vitamin D deficiency and type I DM is an
ongoing area of interest. The study aims to identify the prevalence of vitamin D deficiency in …

[HTML][HTML] Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus

MG Shaikh, AK Lucas-Herald, A Dastamani… - Frontiers in …, 2023 - frontiersin.org
Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent
hypoglycaemia in infants and young children caused by inappropriate insulin over …

[HTML][HTML] The molecular mechanisms, diagnosis and management of congenital hyperinsulinism

S Senniappan, VB Arya, K Hussain - Indian journal of …, 2013 - journals.lww.com
Congenital hyperinsulinism (CHI) is the result of unregulated insulin secretion from the
pancreatic β-cells leading to severe hypoglycaemia. In these patients it is important to make …