Urbanicity has been repeatedly associated with increased incidence of schizophrenia. This
article (a) presents results of a prospective study of urbanicity and schizophrenia in Ireland …

Cardiac involvement drives prognosis and treatment choices in cardiac amyloidosis.
Echocardiography is the first-line examination for patients presenting with heart failure, and …

Purpose of review This review article discusses the evolution of extracellular volume (ECV)
quantification using both cardiovascular magnetic resonance (CMR) and computed …

BACKGROUND: Adverse early life events are associated with a maladaptive stress
response system and might increase the vulnerability to disease in later life. Several …

Background & Aims: Irritable bowel syndrome (IBS) is a functional disorder with an etiology
that has been linked to both psychological stress and infection. The primary aim of this study …

Host defence against infection requires a range of innate and adaptive immune responses
that may lead to tissue damage. Such immune-mediated pathologies can be controlled with …

OBJECTIVE: Approximately 30% of patients with depression fail to respond to a selective
serotonin reuptake inhibitor (SSRI). Few studies have attempted to define these patients …

Background Older patients with severe aortic stenosis (AS) are increasingly identified as
having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse …

BACKGROUND: The role of the immune system in mood disorders is predominately
supported by studies in unipolar major depression. However activation of the immune …

Background—Calcific aortic stenosis (cAS) affects 3% of individuals aged> 75 years,
leading to heart failure and death unless the valve is replaced. Wild-type transthyretin …