[HTML][HTML] The mTOR signalling pathway in human cancer
The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …
Melanoma treatment in review
Melanoma represents the most aggressive and the deadliest form of skin cancer. Current
therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy …
therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy …
Towards process-informed bias correction of climate change simulations
Biases in climate model simulations introduce biases in subsequent impact simulations.
Therefore, bias correction methods are operationally used to post-process regional climate …
Therefore, bias correction methods are operationally used to post-process regional climate …
[HTML][HTML] Factors associated with COVID-19 vaccine hesitancy
It is critical to develop tailored strategies to increase acceptability of the COVID-19 vaccine
and decrease hesitancy. Hence, this study aims to assess and identify factors associated …
and decrease hesitancy. Hence, this study aims to assess and identify factors associated …
[HTML][HTML] Frequency of TERT promoter mutations in human cancers
Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying
mechanisms remain poorly understood. Here we report the presence of recurrent somatic …
mechanisms remain poorly understood. Here we report the presence of recurrent somatic …
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC
P Soares, V Trovisco, AS Rocha, J Lima, P Castro… - Oncogene, 2003 - nature.com
Rearrangement of RET proto-oncogene is the major event in the etiopathogenesis of
papillary thyroid carcinoma (PTC). We report a high prevalence of BRAF V599E mutation in …
papillary thyroid carcinoma (PTC). We report a high prevalence of BRAF V599E mutation in …
[HTML][HTML] Correcting for purifying selection: an improved human mitochondrial molecular clock
There is currently no calibration available for the whole human mtDNA genome,
incorporating both coding and control regions. Furthermore, as several authors have pointed …
incorporating both coding and control regions. Furthermore, as several authors have pointed …
TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas
…, M Sobrinho-Simões, P Soares - The Journal of …, 2014 - academic.oup.com
Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-
derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers …
derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers …
The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one …
Objectives: We sought to evaluate the relative efficacies of three possible therapeutic
strategies for patients with multivessel coronary artery disease (CAD), stable angina, and …
strategies for patients with multivessel coronary artery disease (CAD), stable angina, and …
Sensitivity of moist convection to environmental humidity
SH Derbyshire, I Beau, P Bechtold… - Quarterly Journal of …, 2004 - Wiley Online Library
As part of the EUROCS (EUROpean Cloud Systems study) project, cloud‐resolving model
(CRM) simulations and parallel single‐column model (SCM) tests of the sensitivity of moist …
(CRM) simulations and parallel single‐column model (SCM) tests of the sensitivity of moist …