User profiles for "author:P Soares"

Paula Soares

- Verified email at ipatimup.pt - Cited by 17053

Pedro A. Soares

- Verified email at bio.uminho.pt - Cited by 7240

PAULO ROGERIO SOARES

- Verified email at hc.fm.usp.br - Cited by 3257

[HTML][HTML] The mTOR signalling pathway in human cancer

H Pópulo, JM Lopes, P Soares - International journal of molecular …, 2012 - mdpi.com
The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …

Melanoma treatment in review

B Domingues, JM Lopes, P Soares… - ImmunoTargets and …, 2018 - Taylor & Francis
Melanoma represents the most aggressive and the deadliest form of skin cancer. Current
therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy …

Towards process-informed bias correction of climate change simulations

D Maraun, TG Shepherd, M Widmann, G Zappa… - Nature Climate …, 2017 - nature.com
Biases in climate model simulations introduce biases in subsequent impact simulations.
Therefore, bias correction methods are operationally used to post-process regional climate …

[HTML][HTML] Factors associated with COVID-19 vaccine hesitancy

P Soares, JV Rocha, M Moniz, A Gama, PA Laires… - Vaccines, 2021 - mdpi.com
It is critical to develop tailored strategies to increase acceptability of the COVID-19 vaccine
and decrease hesitancy. Hence, this study aims to assess and identify factors associated …

[HTML][HTML] Frequency of TERT promoter mutations in human cancers

…, J Lima, V Máximo, P Soares - Nature …, 2013 - nature.com
Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying
mechanisms remain poorly understood. Here we report the presence of recurrent somatic …

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

P Soares, V Trovisco, AS Rocha, J Lima, P Castro… - Oncogene, 2003 - nature.com
Rearrangement of RET proto-oncogene is the major event in the etiopathogenesis of
papillary thyroid carcinoma (PTC). We report a high prevalence of BRAF V599E mutation in …

[HTML][HTML] Correcting for purifying selection: an improved human mitochondrial molecular clock

P Soares, L Ermini, N Thomson, M Mormina… - The American Journal of …, 2009 - cell.com
There is currently no calibration available for the whole human mtDNA genome,
incorporating both coding and control regions. Furthermore, as several authors have pointed …

TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas

…, M Sobrinho-Simões, P Soares - The Journal of …, 2014 - academic.oup.com
Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-
derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers …

The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: one …

W Hueb, PR Soares, BJ Gersh, LAM César… - Journal of the American …, 2004 - jacc.org
Objectives: We sought to evaluate the relative efficacies of three possible therapeutic
strategies for patients with multivessel coronary artery disease (CAD), stable angina, and …

Sensitivity of moist convection to environmental humidity

SH Derbyshire, I Beau, P Bechtold… - Quarterly Journal of …, 2004 - Wiley Online Library
As part of the EUROCS (EUROpean Cloud Systems study) project, cloud‐resolving model
(CRM) simulations and parallel single‐column model (SCM) tests of the sensitivity of moist …