Millions of people across the world have sickle cell disease (SCD). Although the true
prevalence of SCD in Europe is not certain, London (UK) alone had an estimated 9000 …

Sickle cell disease (SCD) and thalassaemia are genetic disorders that are caused by errors
in the genes for haemoglobin and are some of the most common significant genetic …

Sickle cell disease (SCD) is characterised by intermittent episodes of acute severe pain,
related to vaso‐occlusion. Environmental factors are thought to play an important role, and …

Objective To evaluate England's NHS newborn sickle cell screening programme
performance in children up to the age of 5 years. Design Cohort of resident infants with …

Objectives To prospectively assess longitudinal lung function in children with sickle cell
disease (SCD). Working hypothesis Lung function in SCD children deteriorates with …

The clinical severity of sickle‐cell disease (SCD) is dependent on genetic and
environmental variables. Environmental factors have been poorly studied. We have …

Summary Objectives and Working Hypothesis Airways obstruction occurs in young children
with sickle cell disease (SCD). Our aim was to test the hypothesis that increased pulmonary …

Sickle cell disease (SCD) comprises a group of recessively inherited blood disorders and is
the most common genetic disorder in the world (Embury et al., 1994). It is a chronic condition …

Serum lactate dehydrogenase (LDH) levels were studied in children with HbSS and HbSC
in a single institution, and their relationship to cerebral vasculopathy as assessed by …

Low nocturnal oxygen saturation (SpO 2) is implicated in complications of Sickle Cell
Anemia (SCA). Twenty-four children with SCA were randomized to receive overnight auto …