Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Background Inhaled corticosteroids form the main therapy for asthma, but there is increasing
concern about the potential systematic effects of long‐term inhaled corticosteroids including …

Background Pulmonary rehabilitation seems to be an effective intervention in patients with
chronic obstructive pulmonary disease. We undertook a randomised controlled trial to …

A randomised controlled trial with a factorial design was done to examine the effects of
dietary intervention in the secondary prevention of myocardial infarction (MI). 2033 men who …

Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to
subvert T-cell-mediated immunosurveillance,. The success of therapies that disrupt PD-L1 …

The results of a randomized controlled trial of a single daily dose of acetyl salicylic acid
(aspirin) in the prevention of reinfarction in 1,239 men who had had a recent myocardial …

We combined data from 5 prospective studies to compare the death rates from common
diseases of vegetarians with those of nonvegetarians with similar lifestyles. A summary of …

Objective: To see whether mortality among men with angina can be reduced by dietary
advice. Design: A randomized controlled factorial trial. Setting: Male patients of general …

In 1973 a survey was conducted among 12 year old children living in a defined area of
South Wales. In 1988 the survey was repeated in the same area, again among 12 year old …

Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …