This article provides an overview of methods for reliability assessment of quantitative
structure-activity relationship (QSAR) models in the context of regulatory acceptance of …

As the use of Quantitative Structure Activity Relationship (QSAR) models for chemical
management increases, the reliability of the predictions from such models is a matter of …

Species in the environment vary according to their sensitivity to a toxicant. Because these
differences in sensitivity are unique to the toxicant at consideration and laboratory data sets …

This is the 52nd report of a series of workshops organised by the European Centre for the
Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in …

Although the concept of similarity is a convenient for humans, a formal definition of similarity
between chemical compounds is needed to enable automatic decision‐making. The …

Sensitization, the prerequisite event in the development of allergic contact dermatitis, is a
key parameter in both hazard and risk assessments. The pathways involved have recently …

This article is a review of the use of quantitative (and qualitative) structure-activity
relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute …

Skin sensitization is a key endpoint for cosmetic ingredients, with a forthcoming ban for
animal testing in Europe. Four alternative tests have so far been submitted to ECVAM …

Systemic toxicity testing forms the cornerstone for the safety evaluation of substances.
Pressures to move from traditional animal models to novel technologies arise from various …

The" Workshop on Regulatory Use of (Q) SARs for Human Health and Environmental
Endpoints," organized by the European Chemical Industry Council and the International …