Five boys with familial cytomegalic adrenocortical hypoplasia have been followed up for an
average of 19 years. Despite treatment with replacement corticosteroids, all 5 failed to show …

We report a female case of orofaciodigital syndrome type I (OFD I) associated with polycystic
kidneys and agenesis of the corpus callosum. She had chronic renal failure requiring …

A boy, diagnosed as having Addison's disease due to idiopathic atrophy of the adrenal
glands at the age of 7 years, developed the first evidence of what was originally thought to …

Just over 60 years have elapsed since Still's (1897) classical description of rheumatoid
disease in children, yet, despite extensive study, the patho-genesis remains obscure. To …

Following enzyme hydrolysis of the urine of infants aged 1 to 6 days, the neutral steroids
have been extracted and their excretion patterns determined using a method based on …

Case Report AL, a boy, was born in Dundee, on April 8, 1956 after a normal pregnancyand
labour and weighed 7 lb. 6 oz.(3,345 g.). He was breast fed for two weeks and then given …

Materials and Methods In 1958, we undertook a study of the urinary excretion of adrenal
steroids in 31 male full-term infants and 13 male premature infants, to determine the adrenal …

Results Measurement of 21-hydroxypregnenolone in 18 complete 24-hour urine specimens
obtained on days 1, 2, or 3 from 10 normal infants born at term has given a rangeof values …

Despite the long recognition of diabetes as a clinical entity, no successful method of treating
the disease existed until the nineteenth century, when Rollo and Bourchadat discovered …

SUMMARY A method is described for the separation and estimation of neutral steroids in
infant urine. The free steroids are obtained by a two-stage enzyme hydrolysis. Following …