It was accomplished a prospective study with 100 pediatric patients (60 children- and 40 girls) with the diagnoses of chronic rhinitis and bronchial asthma and reactivity allergic to three or more antigens environmental related to exacerbation of disease and whose symptoms were impeding a normal life. It was then included in a program of immunotherapy in compliance with the plan that has in the Centro Regional para la Prevención y el Tratamiento de las Enfermedades Alérgicas (CRPTEA) of the Hospital Universitario de la Universidad Autónoma de Nuevo León, as well as an education and rehabilitation program of the patient and family. There was a notable improvement, clinically demonstrated by the important decrease in the quantity of asthmatic crises and rapid answer to drugs, being integrated to a life of better quality, with good scholastic exploitation, suitable allowance to exercise and quiet sleep. It was concluded that, in well selected asthmatic patients, it is justified the immunotherapy, when it can be demonstrated specific sensitisation to allergens by tests cutaneous and that unfetter the symptoms and that they do not answer adequately to pharmacotherapy of first line.