Abstract
Mutations in a number of lymphoid signaling molecules lead to immunodeficiencies in mice and humans. Among these, one very pleiotropic syndrome results from deficiencies in an array of cytokine signaling pathways utilizing a cytokine receptor common gamma chain, gammac, and the tyrosine kinase Jak3. Recent advances in our understanding of the role of gammac and Jak3 in lymphocyte development and function highlight the importance of cytokine receptor signaling pathways in regulating lymphoid homeostasis and responsiveness.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Clonal Deletion
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Cytokines / physiology
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Hematopoiesis
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Immunologic Deficiency Syndromes / enzymology*
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Immunologic Deficiency Syndromes / genetics
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Immunologic Deficiency Syndromes / immunology
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Immunologic Memory
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Janus Kinase 3
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Lymphocyte Activation
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Mice
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Mice, Knockout
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Phosphorylation
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Protein Processing, Post-Translational
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Protein-Tyrosine Kinases / deficiency
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / physiology*
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Severe Combined Immunodeficiency / enzymology
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Severe Combined Immunodeficiency / genetics
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Severe Combined Immunodeficiency / immunology
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Signal Transduction
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T-Lymphocyte Subsets / immunology
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Thymus Gland / cytology
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Thymus Gland / immunology
Substances
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Cytokines
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Protein-Tyrosine Kinases
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Jak3 protein, mouse
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Janus Kinase 3