Only 7 cases of human poisoning with amitraz have been previously published and most of them are poorly documented. Four additional cases are now reported. The symptoms observed were remarkably similar in all cases: all patients experienced drowsiness; 3 presented with bradycardia, miosis and/or hyperglycemia; 2 developed hypotension and/or vomiting. These symptoms are compared to those observed in previous human or animal poisoning. Alpha 2-adrenoceptor stimulation could explain the clinical and laboratory features in most cases.