In 58 atopic dermatitis patients from 93 was determined the total and specific IgE. Majority of the cases (84.5%) were extrinsic in type and it is an evidence for the local (through the body surfaces) crossing route of allergens. Thus the body surfaces are the most important factors in case of host defense in the first line. To investigate the local defending factors, the body fluids (whole saliva and tear taken from patients, n = 11) were examined too (preliminary study). According to amount of IgA and IgA/IgG ratio, the tear proved to be pure glandular secretum. In the further sistemically arranged study the sera and tear samples were simultaneously examined (n = 35). In follows is scheduled the measurement of total and specific IgE not only in sera, but the tear sample of patients.