Abstract
The presence of interleukin (IL)-1 receptor antagonist (IRAP) in plasma and sputum from patients with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa lung infection was investigated together with IL-1 alpha, IL-1 beta, IL-6, and tumor necrosis factor-alpha (TNF) in a cross-sectional study. All cytokines were assayed by ELISAs. High concentrations of IRAP, IL-1 alpha, IL-1 beta, IL-6, and TNF in sputum samples and low or nondetectable levels of circulating cytokines were frequently found. Increased concentrations of plasma IRAP are positively correlated with decreasing pulmonary function. In a longitudinal study of serum IRAP, a higher level of IRAP was detected in a group of patients with poor pulmonary function compared to a group with good pulmonary function.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Chronic Disease
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Cross-Sectional Studies
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Cystic Fibrosis / complications
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Cystic Fibrosis / immunology
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Cystic Fibrosis / pathology*
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Female
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Forced Expiratory Volume
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Humans
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Inflammation
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1 / analysis
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Interleukin-6 / analysis
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Interleukins / analysis*
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Longitudinal Studies
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Lung / pathology
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Male
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Pseudomonas Infections / complications*
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Pseudomonas Infections / pathology
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Respiratory Tract Infections / complications*
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Respiratory Tract Infections / pathology
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Sialoglycoproteins / analysis*
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Sputum / immunology
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Tumor Necrosis Factor-alpha / analysis*
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Vital Capacity
Substances
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IL1RN protein, human
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Interleukin-6
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Interleukins
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Sialoglycoproteins
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Tumor Necrosis Factor-alpha