Coexistence of glucocorticoid receptor and pharmacokinetic abnormalities: factors that contribute to a poor response to treatment with glucocorticoids in children with asthma

A K Kamada; J D Spahn; W Surs; E Brown; D Y Leung; S J Szefler

doi:10.1016/s0022-3476(05)83198-1

Coexistence of glucocorticoid receptor and pharmacokinetic abnormalities: factors that contribute to a poor response to treatment with glucocorticoids in children with asthma

J Pediatr. 1994 Jun;124(6):984-6. doi: 10.1016/s0022-3476(05)83198-1.

Authors

A K Kamada¹, J D Spahn, W Surs, E Brown, D Y Leung, S J Szefler

Affiliation

¹ Ira. J. and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

PMID: 8201491
DOI: 10.1016/s0022-3476(05)83198-1

Abstract

Rapid glucocorticoid clearance and abnormal glucocorticoid receptor binding have been described as factors that contribute to an inadequate response to treatment with glucocorticoids in patients with asthma. We report the coexistence of these abnormalities in children with severe asthma who respond poorly to systemic glucocorticoid therapy.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adolescent
Asthma / drug therapy*
Asthma / metabolism
Child
Female
Humans
Male
Metabolic Clearance Rate
Methylprednisolone / pharmacokinetics*
Methylprednisolone / therapeutic use
Prednisolone / pharmacokinetics*
Prednisolone / therapeutic use
Receptors, Glucocorticoid*

Substances

Receptors, Glucocorticoid
Prednisolone
Methylprednisolone

Grants and funding

HL-36577/HL/NHLBI NIH HHS/United States