Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone

Miguel Debono; Robert F Harrison; Martin J Whitaker; David Eckland; Wiebke Arlt; Brian G Keevil; Richard J Ross

doi:10.1210/jc.2015-3694

Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone

J Clin Endocrinol Metab. 2016 Apr;101(4):1469-77. doi: 10.1210/jc.2015-3694. Epub 2016 Jan 26.

Authors

Miguel Debono¹, Robert F Harrison¹, Martin J Whitaker¹, David Eckland¹, Wiebke Arlt¹, Brian G Keevil¹, Richard J Ross¹

Affiliation

¹ The University of Sheffield (M.D., R.F.H., M.J.W., R.J.R.), Sheffield S10 2RX, United Kingdom; Diurnal Limited (D.E.), Cardiff, United Kingdom; Institute of Metabolism and Systems Research (W.A.), University of Birmingham, Birmingham, B15 2TT, United Kingdom; and Department of Clinical Biochemistry (B.G.K.), University Hospital South Manchester, Manchester M23 9LT, United Kingdom.

PMID: 26812690
DOI: 10.1210/jc.2015-3694

Abstract

In this study we tested the use of salivary cortisol and cortisone as alternatives to serum cortisol. Salivary cortisol is often undetectable and contaminated by hydrocortisone. Salivary cortisone strongly reflects serum cortisol.

Publication types

Clinical Trial

MeSH terms

Adult
Chromatography, Liquid
Circadian Rhythm
Cortisone / analysis*
Cross-Over Studies
Humans
Hydrocortisone / metabolism*
Male
Prospective Studies
Saliva / chemistry*
Salivary Glands / metabolism*
Salivary Glands / pathology
Tandem Mass Spectrometry

Substances

Cortisone
Hydrocortisone

Abstract

Publication types

MeSH terms

Substances

Grants and funding