The experience gained from the application of an on-going multilevel intervention programme through an interdisciplinary team approach to the management of 30 HIV-positive children, adolescents and young people aged from 7 to 21 years (20 haemophiliac and 10 thalassaemic patients) and their families is described. The objective of the intervention was to assess the family's needs, to help parents and other family members to contain the anxiety of seropositive children and to improve their interraction with the family as well as with others in their social environment. The intervention was also designed to help family members to cope with their grief. Work with the medical and nursing staff, on the other hand, was intended to increase their understanding of the emotions caused in them by occupational stress, such as fear, anxiety, prejudice and feelings of guilt related to the iatrogenous nature of the infection. The need for follow-up studies is stressed to allow assessment of the effectiveness of the intervention and to search for protective factors, successful coping skills, strategies and adaptational resources.