Abstract
Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Celiac Disease / genetics
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Celiac Disease / immunology*
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Celiac Disease / physiopathology
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Clinical Trials as Topic
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GTP-Binding Proteins
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Gliadin / immunology
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Gliadin / metabolism
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HLA-DQ Antigens / genetics
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HLA-DQ Antigens / metabolism
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Humans
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Intestinal Mucosa / immunology
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases / genetics
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Transglutaminases / metabolism
Substances
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HLA-DQ Antigens
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HLA-DQ2 antigen
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HLA-DQ8 antigen
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Gliadin
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Protein Glutamine gamma Glutamyltransferase 2
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Transglutaminases
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GTP-Binding Proteins