Abstract
Idiopathic thrombocytopenic purpura in children 10 years of age or younger was observed to have a more favorable prognosis than in older children. Corticosteroid therapy in children judged to be at increased risk of serious hemorrhage resulted in a significantly greater number of patients with an early increase in platelets than was noted in a control group. All patients with chronic disease who responded to administration of a corticosteroid initially and then relapsed had some response to a subsequent course of therapy, although none had a sustained remission. In such patients, splenectomy was a more effective therapeutic measure than treatment with either a corticosteroid or a cytotoxic agent.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / blood
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Adrenal Cortex Hormones / therapeutic use*
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Adrenocorticotropic Hormone / administration & dosage
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Adrenocorticotropic Hormone / therapeutic use
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Age Factors
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Azathioprine / adverse effects
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Azathioprine / therapeutic use
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Blood Platelets / analysis
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Child
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Child, Preschool
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Cortisone / therapeutic use
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Female
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Hemorrhage / drug therapy
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Hemorrhage / etiology
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Hemorrhage / prevention & control*
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Hemostasis
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Humans
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Immunosuppressive Agents / therapeutic use*
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Infant
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Male
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Methylprednisolone / therapeutic use
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Prednisone / therapeutic use
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Purpura, Thrombocytopenic / blood
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Purpura, Thrombocytopenic / complications
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Purpura, Thrombocytopenic / therapy*
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Seasons
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Splenectomy
Substances
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Adrenal Cortex Hormones
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Immunosuppressive Agents
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Adrenocorticotropic Hormone
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Azathioprine
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Cortisone
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Prednisone
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Methylprednisolone