Article Text
Abstract
Aims: In order to evaluate the efficacy of a school urinary screening programme, children with membranoproliferative glomerulonephritis (MPGN) type 1 were studied.
Methods: A total of 52 patients who had been diagnosed with MPGN type 1 from 1970 to 1997 were studied; 35 were identified after 1974 on screening (group S), and 17 were identified by presenting symptoms (group N), mostly before 1989.
Results: Mean blood pressure was 89 mm Hg in group S and 104 mm Hg in group N; urinary protein excretion was 0.9 g/day in group S and 3.0 g/day in group N. Histopathological evidence of chronic changes was found in six group S and 15 group N patients. No patients in group S had renal insufficiency, but five patients in group N required regular haemodialysis.
Conclusions: Results suggest that early identification by school urinary screening may enable early management and so improve prognosis of MPGN.
- membranoproliferative glomerulonephritis
- urinary screening
- school
- prognosis
- BUN, blood urea nitrogen
- EM, electron microscopy
- IF, immunofluorescence
- Ig, immunoglobulin
- LM, light microscopy
- MD, mesangial deposit
- MPGN, membranoproliferative glomerulonephritis
- SEND, subendothelial deposit
- SEPT, subepithelial deposit
- SUS, school urinary screening
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