Original ArticleDecreased prevalence of atopic diseases in children with diabetes☆,☆☆
Section snippets
Study Design and Methods
The 8 participating centers had developed population-based registers of childhood-onset diabetes that had operated since 1989 and were validated by the standards of EURODIAB ACE6: Austria, Latvia, Lithuania, Luxembourg, Romania, Bulgaria, Leeds (UK), and Northern Ireland (UK). Altogether, 1204 patients with onset of diabetes before the age of 15 years and 3606 members of a population-based control group selected within age strata compatible with the age distribution of cases were invited to the
Results
Table II shows the odds ratios and 95% confidence limits for the association between asthma and childhood- onset insulin-dependent diabetes mellitus by center.The Mantel-Haenszel combined odds ratio was significantly decreased (P =.008) for asthma, with no evidence of heterogeneity among centers (Table II). The combined odds ratios for atopic eczema was not decreased, and there was heterogeneity among centers. This heterogeneity was mainly due to the high odds ratio in the Bulgarian center.
Discussion
This multicenter case control study showed a decreased prevalence of atopic diseases, particularly asthma, in children with diabetes, suggesting that the occurrence of atopic diseases may protect against the development of type 1 diabetes. This protective effect was not observed in the 2 younger age groups (0 to 4 years and 5 to 9 years), but all 3 expressions of atopic diseases were markedly inversely related to type 1 diabetes diagnosed between 10 and 14 years of age. This age-dependent
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Cited by (0)
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This study is part of the EURODIAB ACE study granted by the Biomed I and II programmes from the European Union. Local grants were supplied from the Swedish Medical Research Council, project number 07531, The Swedish Diabetes Association, the British Diabetic Association, the Hungarian National Research Fund, (project number 019192), and CRP-Sauté, Luxembourg. *The participating investigators are listed in the Appendix.
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Reprint requests: G. Soltész, Department of Paediatrics, University Medical School of Pécs, H-7623 Pécs, József A. u. 7.
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*The participating investigators are listed in the Appendix.