Despite the huge size of the HIV population in an infected patient, chance has an unexpected influence on its evolution.
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Leigh Brown, A., Richman, D. HIV-1: Gambling on the evolution of drug resistance?. Nat Med 3, 268–271 (1997). https://doi.org/10.1038/nm0397-268
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DOI: https://doi.org/10.1038/nm0397-268