Original ArticleA National Prospective Study on Childhood Celiac Disease in the Netherlands 1993–2000: An Increasing Recognition and a Changing Clinical Picture
Section snippets
Data Collection
All newly diagnosed cases of childhood CD throughout the Netherlands were registered prospectively from 1993 to 2000 by means of the Dutch Pediatric Surveillance Unit, founded in 1992 under the auspices of the Dutch Society for Pediatrics. The Unit requested all pediatricians working in general hospitals to report each month regardless of whether they had diagnosed children with CD. In the 8 University Medical Centers, a specific contact person was nominated to report. Private pediatric clinics
Response
More than 90% of the contacted Dutch pediatricians returned the monthly card to the Dutch Pediatric Surveillance Unit during the period of 1993–2000, and they reported that 1778 children had newly diagnosed CD.
Ascertainment
From the children reported by the pediatricians, 39% did not fulfill the inclusion criteria: 496 children were reported twice or were diagnosed outside the study period, 93 were diagnosed without small bowel biopsy, or the results of the biopsy were not compatible with CD, 48 children had
Discussion
We have performed a prospective nation-wide study on all newly diagnosed cases of childhood CD in the Netherlands from1993 to 2000. The pediatricians' high response to the Dutch Pediatric Surveillance Unit, as well as the ascertainment of the diagnosis of CD by means of the data of PALGA, strongly indicate that our study population is representative for the average child with newly diagnosed CD in the Netherlands. Eight percent of the children with newly diagnosed CD had at least 1 parent from
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This study was partially supported by Preventiefonds/ZON, the Netherlands.