Trends in Genetics
Volume 13, Issue 1, January 1997, Pages 14-21
Journal home page for Trends in Genetics

Review
The world according to bedgebog

https://doi.org/10.1016/S0168-9525(96)10051-2Get rights and content

Abstract

Members of the Hedgebog family of signaling molecules mediate many important short- and long-range patterning processes during invertebrate and vertebrate development. In the fly, a single bedgebog gene regulates segmental and imaginal disc patterning. In contrast, in vertebrates a bedgebog gene family is involved in the control of left-right asymmetry, polarity in the central nervous system (CNS), somites and limb, organogenesis, chondrogenesis and spermatogenesis. Here, we review recent experiments addressing the function of the various Hedgebog members during invertebrate and vertebrate development.

References (93)

  • J.J. Lee et al.

    Cell

    (1992)
  • S.C. Ekker

    Curr. Biol.

    (1995)
  • H. Roelink

    Cell

    (1995)
  • J.A. Porter

    Cell

    (1996)
  • C-M. Fan

    Cell

    (1995)
  • T-K.H. Vu et al.

    Cell

    (1991)
  • Y. Tanabe et al.

    Curr. Biol.

    (1995)
  • J. Heemskerk et al.

    Cell

    (1994)
  • A.M. Taylor et al.

    Mech. Dev.

    (1993)
  • T. Tabata et al.

    Cell

    (1994)
  • G. Struhl et al.

    Cell

    (1993)
  • P.W. Ingham et al.

    Curr. Biol.

    (1995)
  • U. Heberlein et al.

    Cell

    (1993)
  • C. Ma et al.

    Cell

    (1993)
  • Z. Huang et al.

    Cell

    (1996)
  • S. Krauss et al.

    Cell

    (1993)
  • Y. Echelard

    Cell

    (1993)
  • H. Roelink

    Cell

    (1994)
  • R.D. Riddle et al.

    Cell

    (1993)
  • M. Levin

    Cell

    (1995)
  • T. Yamada et al.

    Cell

    (1993)
  • M. Hynes

    Neuron

    (1995)
  • J. Ericson

    Cell

    (1995)
  • R.L. Johnson et al.

    Cell

    (1994)
  • C-M. Fan et al.

    Cell

    (1994)
  • E. Laufer

    Cell

    (1994)
  • M.J. Bitgood et al.

    Dev. Biol.

    (1995)
  • M. Bitgood et al.

    Curr. Biol.

    (1996)
  • N. Perrimon

    Cell

    (1996)
  • J. Hooper et al.

    Cell

    (1989)
  • J. Alcedo

    Cell

    (1996)
  • P. Thérond

    Mech. Dev.

    (1993)
  • D. Kalderon

    Curr. Biol.

    (1995)
  • H. Hahn

    Cell

    (1996)
  • V. Marigo

    Genomics

    (1995)
  • C. Nüsslein-Volhard et al.

    Nature

    (1980)
  • J. Mohler et al.

    Development

    (1992)
  • T. Tabata et al.

    Genes Dev.

    (1992)
  • S. Tashiro

    Gene

    (1993)
  • D.E. Chang

    Development

    (1994)
  • J.J. Lee

    Science

    (1994)
  • D.A. Bumcrot et al.

    Mol. Cell. Biol.

    (1995)
  • J.A. Porter

    Nature

    (1995)
  • C.J. Lai et al.

    Development

    (1995)
  • E. Martí

    Development

    (1995)
  • M.J. Fietz

    Curr. Biol.

    (1995)
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