Elsevier

The Lancet

Volume 363, Issue 9404, 17 January 2004, Pages 212-214
The Lancet

Research Letters
Proportion of tuberculosis transmission that takes place in households in a high-incidence area

https://doi.org/10.1016/S0140-6736(03)15332-9Get rights and content

Summary

The prevalence of infection among household contacts of people with tuberculosis is high. This information frequently guides active case finding. We analysed DNA fingerprints of Mycobacterium tuberculosis from 765 tuberculosis patients in Ravensmead and Uitsig, adjacent suburbs of Cape Town, South Africa. In 129 households in which DNA fingerprints were available for more than one patient, we identified 313 patients, of whom 145 (46%) had a fingerprint pattern matching that of another member of the household. The proportion of transmission in the community that took place in the household was 19%, and therefore, in this high-incidence area, tuberculosis transmission occurs mainly outside the household.

References (6)

  • LockmanS et al.

    Molecular and conventional epidemiology of Mycobacterium tuberculosis in Botswana: a population-based prospective study of 301 pulmonary tuberculosis patients

    J Clin Microbiol

    (2001)
  • ClassenCN et al.

    Impact of social interactions in the community on the transmission of tuberculosis in a high incidence area

    Thorax

    (1999)
  • Van RieA et al.

    Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment

    N Engl J Med

    (1999)
There are more references available in the full text version of this article.

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