Natural course of sensitization to food and inhalant allergens during the first 6 years of life☆,☆☆,★
Section snippets
Study population
Subjects in this study were participants of the MAS. A detailed description of the 1314 study subjects and methods is presented elsewhere.16 Briefly, in 1990 all 7609 newborns were enrolled in 6 obstetric departments in 5 German cities. For 5051 children, data about atopic family history and cord blood IgE (CB-IgE) was available. There were no significant differences between the total sample and the 5051 children with respect to the main characteristics given in Table I.Of these subjects, 499
RESULTS
A description of the population-based sample and the analyzed subcohort with regard to the weighting factors and other perinatal characteristics available for both samples are given in Table I. The differences in respect to the 2 atopic risk factors (atopic family history and elevated CB-IgE level) were due to the study design but were adjusted for in the analysis. The subsample corresponded to the population-based sample with regard to the other characteristics.
We were unable to detect sIgE to
DISCUSSION
To our knowledge, this is the first study with a complete and consecutive follow-up of sIgE measurements of over 200 children from birth to 6 years of age that allows estimates for a large population-based sample. Previous reports regarding specific allergic sensitization often relied on small sample sizes in the respective age groups, on selected groups of subjects (eg, children at risk for atopy), or both.1, 3, 4, 5, 6, 7, 18, 19, 20 Reports of prevalence rates were mostly based on
Acknowledgements
We thank C. P. Bauer, F. Bieber, G. Edenharter, J. Forster, C. Genzel, M. Goetz, M. Groeger, B. Hampel, G. Leskosek, R. Mayrl, C. Sommerfeld, and P. Wagner for their contributions to the MAS-90 study.
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Supported by the German Ministry of Research and Technology (BMFT), grant no. 01EE9406.
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Reprint requests: Michael Kulig, MD, MPH, c/o Prof Ulrich Wahn, Department of Pediatric Pneumology and Immunology, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
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