Fatal obliterative coronary vasculitis in Kawasaki disease☆,☆☆,★
Section snippets
Case Report
A 3 ½-year-old black child with a history of asthma had signs of lower respiratory infection and reactive airway disease. He received antibiotics, inhaled and systemic steroids, and ibuprofen. Ten days later his respiratory symptoms improved, and during the next 3 days he had fever to 101°F, a rash, scleral injection, peeling of the skin in the groin area, oral mucous membrane changes, edema of his hands and feet, and bilateral inguinal adenopathy. After 4 days of these symptoms, Kawasaki
Discussion
Angiographic or echocardiographic resolution of mild coronary artery dilatation or smaller aneurysms after Kawasaki disease is common.5 Pathologic studies suggest that intimal proliferation results in remodeling of the enlarged coronary lumen.6, 7 However, recent literature suggests that late coronary events might occur in such patients. Kurisu et al8 demonstrated that coronary arteries that were “normal” on angiographic evaluation had late vasomotor dysfunction, presumably from endothelial
References (10)
- et al.
Outcome of coronary artery aneurysms after Kawasaki disease
J Pediatr
(1992) - et al.
Coronary artery caliber in normal children and patients with Kawasaki disease but without aneurysms: an echocardiographic and angiographic study
J Am Coll Cardiol
(1986) - et al.
Regression of aneurysms in Kawasaki disease: a pathological study
J Pediatr
(1982) - et al.
Variation in coronary arterial dimension (distensible abnormality) after disappearing aneurysm in Kawasaki disease
Am Heart J
(1987) - et al.
Exercise capacity and incidence of myocardial perfusion defects after Kawasaki disease in children and adolescents
J Am Coll Cardiol
(1995)
Cited by (0)
- ☆
From the Department of Pathology, East Carolina University School of Medicine, Pediatric Department, Brody Medical Sciences Building, Greenville, North Carolina.
- ☆☆
Reprint requests: Michael Ellis McConnell, MD, Associate Professor of Pediatrics, Division of Pediatric Cardiology, East Carolina University School of Medicine, 600 Moye Blvd, Greenville, NC 27858-4354.
- ★
0022-3476/98/$5.00 + 0 9/22/89012