Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection☆,☆☆,★,★★
Section snippets
Patients
The study population consisted of children admitted between Jan. 1 and April 30, 1993, to one of the following seven pediatric tertiary care hospitals in Canada: Izaak Walton Killam Hospital, Halifax; Le Centre Hospitalier de l'Université Laval, Québec City; Montreal Children's Hospital, Montreal; Children's Hospital of Eastern Ontario, Ottawa; Hospital for Sick Children, Toronto; Winnipeg Children's Hospital, Winnipeg; and British Columbia's Children's Hospital, Vancouver. Because of the
RESULTS
A total of 698 children were enrolled from Jan. 1 to April 30, 1993, at all centers except Winnipeg Children's Hospital, where enrollment continued until June 30, 1993. Nine patients were excluded because they did not have lower respiratory tract illness associated with the RSV infection. Thus 689 patients were included in the analysis.
There was variation in the type of nasopharyngeal specimen submitted for diagnosis. In addition, there was variation in the ability to isolate and subgroup
DISCUSSION
In our previous retrospective study, it was not possible to separate morbidity attributable to RSV infection from that caused by underlying disease.1 Thus this prospective study was performed to determine morbidity attributable to RSV. In addition, we wished to compare prospectively the morbidity in those with underlying illness with that in patients without underlying disease.
The reduced morbidity in a population with underlying heart and lung disease noted in our previous retrospective study,1
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From the Clinical Epidemiology Unit, Hospital for Sick Children, Toronto, Ontario, Canada
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Supported by a grant from Lederle, Canada Inc.
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Reprint requests: Elaine E. L. Wang, MCDM, Clinical Epidemiology Unit, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada.
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0022-3476/95/$3.00 + 09/20/59781