Association of symptoms with Helicobacter pylori infection in children☆,☆☆,★
Section snippets
METHODS
Two hundred fifty-six patients underwent upper gastrointestinal endoscopy between May 1991 and March 1993. During each examination two biopsy specimens were obtained from the first part of the duodenum. In addition, two biopsy specimens were taken from the antral mucosa; one was used for a rapid urease test (Clo, Delta West, Bentley, Western Australia), and the second was sent for histologic assessment. If the rapid urease test result was positive (up to 24 hours), the patient was entered into
RESULTS
Nineteen children had H. pylori infection of the gastric mucosa. The children ranged in age from 6.1 to 14.7 years (mean age ± SD, 11.7 ± 2.5 years). The male/female ratio was 1.4:1. None of these children had a history of alcohol consumption, smoking, or use of nonsteroidal antiinflammatory medication.
DISCUSSION
In our study, H. pylori gastritis, in the absence of duodenal ulcer disease, did not cause symptoms. After eradication of H. pylori , symptoms consistently resolved only in those patients who had duodenal ulcer disease associated with H. pylori gastritis. H. pylori infection is uncommon among children in developed countries, and therefore specific symptoms are easier to identify. Furthermore, smoking, alcohol use, and nonsteroidal antiinflammatory drug ingestion are usually not confounding
References (18)
Helicobacter pylori and the pediatric patient
Gastroenterol Clin North Am
(1993)- et al.
Treatment and long-term follow-up of Helicobacter pylori -associated duodenal ulcer disease in children
J P EDIATR
(1993) A critique of therapeutic trials in Helicobacter pylori -positive functional dyspepsia
Gastroenterology
(1994)- et al.
Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists
Gastroenterology
(1992) - et al.
Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children
N Engl J Med
(1987) - et al.
Intrafamilial clustering of Helicobacter pylori infection
N Engl J Med
(1990) - et al.
Helicobacter pylori and gastrointestinal symptoms
Arch Dis Child
(1994) - et al.
Prevelance of Helicobacter pylori infection and histologic gastritis in asymptomatic persons
N Engl J Med
(1989) - et al.
Helicobacter pylori infection in children: is there specific symptomatology?
Dig Dis Sci
(1994)
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From the Department of Paediatrics and the Department of Public Health Medicine and Epidemiology, University College Dublin, and Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
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Reprint requests: B. Drumm, MD, Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland.
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0022-3476/95/$3.00 + 0 9/22/62347