Double-blind study of ACTH vs prednisone therapy in infantile spasms*
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Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials
2023, European Journal of Paediatric NeurologyComputational characteristics of interictal EEG as objective markers of epileptic spasms
2021, Epilepsy ResearchCitation Excerpt :Although the presence of hypsarrhythmia is often used as a diagnostic marker of the syndrome, there is low inter-rater reliability for identification of the pattern (Hussain et al., 2015; Mytinger et al., 2015) and it is not a predictor of outcome (Demarest et al., 2017). Overall, rates of sustained treatment response are low due to a paucity of effective first-line therapies and a high relapse rate (Hrachovy et al., 1983; Baram et al., 1996; Ito et al., 2002), and this is further complicated by diagnostic challenges and the subsequent use of inappropriate therapies in cases of misdiagnosis (O’Callaghan et al., 2011; Auvin et al., 2012). Computational EEG biomarkers of ES that are independent of the presence of hypsarrhythmia would help address these challenges by providing tools for objective—and perhaps more accurate—identification of the disease.
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Supported by Grant NS11535 and Contract NS-9-2321 from the National Institute of Neurological and Communicative Disorders and Stroke.