Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference†
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Cited by (48)
Paediatric solid oral dosage forms for combination products: Improving in vitro swallowability of minitablets using binary mixtures with pellets
2023, European Journal of Pharmaceutical SciencesThe effect of food vehicles on in vitro performance of pantoprazole sodium delayed release sprinkle formulation
2023, International Journal of PharmaceuticsDetermination of healthcare resource and cost implications of using alternative sodium valproate formulations in the treatment of epilepsy in children in England: A retrospective database review
2021, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Previous research compared a sprinkle formulation (Depakote) to valproic acid syrup (Depakene) in twelve children with epilepsy aged from 5 to 16 years; the sprinkle was preferred by parents and children due to ease of administration and palatability, respectively. Furthermore there were fewer fluctuations in serum concentrations with the sprinkle compared to the syrup [7]. Another study compared the acceptance of a sodium valproate prolonged release microgranule to a liquid product in 199 children; the results showed that refusal to take the medicine decreased upon switching to the microgranule (Micropakine®LP; MPK) as did the frequency that parents were using rewards [8].
Sprinkle formulations—A review of commercially available products
2020, Asian Journal of Pharmaceutical SciencesCitation Excerpt :Sprinkle formulations can improve compliance of patients with dysphagia. Indeed, more than 75% and 93% of children preferred sprinkle dosage form to syrup and oral drops, respectively [26,27]. This preference spurred the growth of sprinkle products since the early 1990s as can be seen in Fig. 1.
The effect of administration media on palatability and ease of swallowing of multiparticulate formulations
2018, International Journal of PharmaceuticsCitation Excerpt :A range of studies showed acceptance of iron supplement sprinkles and preference for these compared to oral drops in children with anaemia (Adu-Afarwuah et al., 2008; Geltman et al., 2009; Zlotkin et al., 2003). Likewise, studies involving children suffering from epilepsy consistently showed preference for sprinkle formulations over syrup (Cloyd et al., 1992; Motte et al., 2005; Verrotti et al., 2012). In a recent study, children showed preference for sprinkles over syrup after 12-week antiretroviral therapy; 72% of children below 12 months and 64% of children between 1 and 4 years preferred the multiparticulate dosage form.
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Supported in part by a grant from Abbott Laboratories.
Presented in part at the annual meeting of the American Epilepsy Society, Baltimore, Md., Dec. 7, 1987.