Original articleAngiotensin converting enzyme inhibitor therapy to decrease microalbuminuria in normotensive children with insulin-dependent diabetes mellitus*
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Cited by (85)
Type 1 Diabetes in Children and Adolescents
2018, Canadian Journal of DiabetesCitation Excerpt :Treatment is indicated only for those adolescents with persistent albuminuria. One short-term randomized controlled trial in adolescents demonstrated that angiotensin-converting enzyme (ACE) inhibitors were effective in reducing albuminuria compared to placebo (163). However, there are no long-term intervention studies assessing the effectiveness of ACE inhibitors or angiotensin receptor blockers (ARBs) in delaying progression to overt nephropathy in adolescents with albuminuria.
An Update on Hypertension in Children With Type 1 Diabetes
2018, Canadian Journal of DiabetesCitation Excerpt :ACEis and ARBs also have antiproteinuric effects, which make them particularly beneficial in children with diabetic nephropathy (87). Multiple observational studies have demonstrated that the use of these medications is associated with reduced microalbuminuria and improved renovascular outcomes (88–90). As well, studies have demonstrated reduced progression of diabetic retinopathy by 50% to 70% (91,92).
Le diabète de type 1 chez les enfants et les adolescents
2013, Canadian Journal of DiabetesCitation Excerpt :Le traitement est indiqué uniquement chez les adolescents qui présentent une microalbuminurie persistante. Un essai de courte durée contrôlé et avec répartition aléatoire mené auprès d’adolescents a démontré que les inhibiteurs de l’enzyme de conversion de l’angiotensine (ECA) étaient plus efficaces qu’un placebo pour réduire la microalbuminurie (114). Toutefois, aucune étude sur le terrain à long terme n’a été menée pour évaluer l’efficacité des inhibiteurs de l’ECA ou des antagonistes du récepteur de l’angiotensine II pour retarder l’évolution vers la néphropathie manifeste chez des adolescents présentant une microalbuminurie.
Type 1 Diabetes in Children and Adolescents
2013, Canadian Journal of DiabetesCitation Excerpt :Treatment is indicated only for those adolescents with persistent microalbuminuria. One short-term randomized controlled trial in adolescents demonstrated that angiotensin-converting enzyme (ACE) inhibitors were effective in reducing microalbuminuria compared to placebo (114). However, there are no long-term intervention studies assessing the effectiveness of ACE inhibitors or angiotensin II receptor antagonists in delaying progression to overt nephropathy in adolescents with microalbuminuria.
2009 operating grant recipient, Dr. Denis Daneman
2010, Canadian Journal of DiabetesTreatment of Childhood Hypertension
2008, Comprehensive Pediatric Nephrology: Text with CD-ROM
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Supported by Squibb Pharmaceuticals. Dr. Cook was supported by a fellowship from the Hospital for Sick Children Foundation.