PaperInsulin-like growth factor (IGF)-I, -II and IGF binding protein-2 (IGFBP-2) in the plasma of children with Wilms' tumour
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Expression of the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs) in human gastric cancer cells
2001, European Journal of CancerCitation Excerpt :The ubiquitous expression of IGFBP-2 in the panel of cell lines studied here suggests that IGFBP-2 is intimately associated with the malignant phenotype, and confers some growth advantage on the tumour cells. Several studies have suggested that IGFBP-2 expression may be associated with malignancy [27,28], but the exact role of IGFBP-2 in tumour development including gastric cancer is not known. Based on the finding that the serum level of IGFBP-2 is increased in various types of tumours, Zumkeller and colleagues [28] concluded that the serum IGFBP-2 measurement could be a useful marker for the diagnosis of various malignancies.
Serum hyaluronan and its association with unfavorable histology and aggressiveness of heterotransplanted wilms' tumour
2000, Journal of Pediatric SurgeryCitation Excerpt :If survival rate is to improve for children with poorly responsive, unfavorable histology tumors, then earlier identification is paramount. A number of factors have been identified in the serum and urine of children with WT, including hyaluronic acid—stimulating activity (HASA), hyaluronidase, basic fibroblast growth factor, insulinlike growth factor-2, renin, and erythropoietin.15-20 Although fluctuations in these markers have been associated with the diagnosis, remission, and recurrence of disease, none has proven to be a reliable predictor of tumor stage, invasiveness, histology, nor, more importantly, unfavorable histology findings.
Analyzing the gene expression profile of anaplastic histology Wilms' tumor with real-time polymerase chain reaction arrays
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