Review articleTreatment of infantile spasms
References (37)
On a peculiar form of infantile convulsions
Lancet
(1841)- et al.
Infantile myoclonic seizures: An evaluation of ACTH and corticosteroid therapy
J Pediatr
(1966) - et al.
The effect of adrenocorticotrophic hormone in epilepsy
J Pediatr
(1950) - et al.
Double-blind study of ACTH vs. prednisone therapy in infantile spasms
J Pediatr
(1983) - et al.
The effect of ACTH therapy on infantile spasms
J Pediatr
(1980) - et al.
The value of neuroradiology in infantile spasms
J Pediatr
(1982) - et al.
Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone
J Pediatr
(1988) - et al.
Precise characterization and quantification of infantile spasms
Ann Neurol
(1979) - et al.
- et al.
Hypsarrhythmia: Variations on the theme
Epilepsia
(1984)
Infantile spasms: A review of the literature and a study of 112 cases
Infantile spasms
Long term prognosis of 150 cases of “West syndrome”
Epilepsia
Diagnosis and management of seizures in children
Infantile spasms, hypsarrhythmia, and mental retardation
JAMA
A prospective study of infantile spasms. Clinical and therapeutic correlations
Epilepsia
ACTH therapy in infantile spasms: Side effects
Arch Dis Child
Observations on the antagonistic effects of posterior pituitary and cortico-adrenal hormones in the epileptic subject
J Clin Endocrinol Metab
Cited by (36)
ACTH Treatment of Infantile Spasms: Low-Moderate- Versus High-Dose, Natural Versus Synthetic ACTH—A Retrospective Cohort Study
2020, Pediatric NeurologyCitation Excerpt :Despite the guidelines by the American Academy of Neurology/Child Neurology Society that were updated in 2012 to describe the equal efficacy of low-dose ACTH3 and high-dose ACTH, the practice of administering high dosages of natural ACTH (150 IU/m2 divided in two daily injections) continues. This is based on a couple of studies in which the response rate was reported to be 90% to 97%.16,18 Results with such a high response rate could, however, not be replicated in a prospective, large national study by Knupp et al.20 In a more recent report from Boston Children’s Hospital, outcome data with once-daily high-dosage practice were reported.19
Adrenocorticotropic Hormone versus Pulsatile Dexamethasone in the Treatment of Infantile Epilepsy Syndromes
2010, Pediatric NeurologyCitation Excerpt :Clear therapeutic strategies concerning administration of steroids are lacking. Studies differ in dosages and therapy periods, and prospective studies are rare [5,6]. Observations differ substantially, and comparison between studies is not valid.
Levetiracetam Monotherapy in Newly Diagnosed Cryptogenic West Syndrome
2007, Pediatric NeurologyCitation Excerpt :Adrenocorticotrophic hormone is the most effective drug in controlling seizures but has frequent and severe, sometimes life threatening side effects. In addition, adrenocorticotrophic hormone efficacy is often transient, and long-term benefits are controversial [13]. Among conventional antiepileptic drugs, valproate and benzodiazepines have been found to be effective in controlled clinical trials of spasms [14].
National survey of West syndrome in Taiwan
2001, Brain and DevelopmentWest syndrome - The University of Hong Kong experience (1970-2000)
2001, Brain and Development