News and featureThe genetics and epidemiology of diabetes in NOD mice
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Comparison of human cord blood engraftment between immunocompromised mouse strains
2010, BloodCitation Excerpt :Collectively, these data suggest that, in addition to immune background, the method of transplantation impacts HSC engraftment, perhaps through mitigation of barriers to HSC migration processes and enhanced immune evasion. NOD mice were originally established in Japan in 1980 from the CTS strain after spontaneous development of insulin-dependent diabetes mellitus with insulitis.13,14 These NOD/ShiJic mice were shipped to Dr E. Leiter at The Jackson Laboratory in 1984 and termed NOD/ShiLt.
Benefits and burden of the maternally-mediated immunological imprinting
2009, Autoimmunity ReviewsCitation Excerpt :Under germfree or specific pathogen-free conditions, NOD-mice spontaneously develop insulin-dependent diabetes mellitus (IDDM) and it was expected that the genetic background of IDDM could be studied in this mouse model. However, immune stimulation [33] as well as inhibition of the transfer of maternal antibodies to the F1 progeny [34] abrogated IDDM development. Hence, maternal antibodies during early ontogeny are decisive for the T cell-dependent destruction of the pancreatic islet β-cells in later life.
Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis
2008, Clinical ImmunologyCitation Excerpt :Moreover, when EAE models are compared in the literature, naturally different mouse colonies were used for studying the disease. However, variable environmental influences have been shown to profoundly affect the outcome of autoimmune processes [36–38]. A major quest in the field should therefore be to consolidate models in a single mouse strain (thereby avoiding the genetic variables) for comparative studies in a single laboratory (thereby avoiding the environmental influences).