ORIGINAL ARTICLESImmunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age
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Cited by (104)
Age-related changes of the human splenic marginal zone B cell compartment
2023, Immunology LettersFactors affecting antibody responses to immunizations in infants born to women immunized against pertussis in pregnancy and unimmunized women: Individual-Participant Data Meta-analysis
2021, VaccineCitation Excerpt :A previous study by Simondon et al showed that infants immunized with a 2-, 4-, 6-month primary immunization schedule had a significantly higher immune response to pertussis (measured by neutralization assay) than infants immunized with a 2-, 3-, 4-month schedule [40]. Similarly, the work by Booy et al showed that immunization with 3-, 5-, 9-months schedule was associated with significantly higher antibody levels against diphtheria and tetanus compared with immunization at 2-, 3-, 4-months [22]. The underlying mechanism for the association between longer intervals between vaccine doses and higher antibody levels requires further investigation.
Immunogenicity and safety of a liquid Pentavalent (DTwP-Hb-Hib) combination vaccine manufactured by Human Biologicals Institute in 6–8 weeks old healthy infants: A phase III, randomized, single blind, non-inferiority study
2019, VaccineCitation Excerpt :A literature search on the subject was conducted and it was found that earlier studies also observed low antibody titre against the tetanus component. In a study published in1992 (on antibody response in infants after one month of vaccination with 3 doses of DTP and Hib conjugate vaccine, concurrently but at separate sites, at the age of 3, 5 and 9 months), Robert Booy et al. reported significantly lower antibody against tetanus toxoid and pertussis antigens in infants in whom pre-immunization (maternally derived) antibody concentrations were high [21]. Adarsh Eregowda et al. reported (in 2013) highly significant rise in antibody titre for all components except tetanus, after one month of vaccination with 3 doses (administered at 6, 10 and 14 weeks of age) of a pentavalent DTwP–HepB–Hib vaccine in Indian infants, which they attributed to presence of maternal antibodies [22].
Pertussis and influenza immunisation during pregnancy: a landscape review
2017, The Lancet Infectious DiseasesCitation Excerpt :In a South African study44 maternal inactivated influenza vaccine administration was 48·8% (11·6–70·4) efficacious for the prevention of influenza in infants. Several studies done in the 1990s and recent data suggest that high maternally derived antibody titres (pre-existing or boosted by Tdap immunisation before or during pregnancy) can have a suppressive effect on infant responses to primary immunisation against pertussis, although the clinical significance of this observation has not been evaluated (table 2).13,18–20,60,85–90 Interference with active immunisation against pertussis was not only affected by the concentrations of maternal antibodies, but also by the type of pertussis vaccine administered to the infant.
Diphtheria Toxoid
2017, Plotkin's VaccinesTetanus Toxoid
2017, Plotkin's Vaccines