Elsevier

The Lancet

Volume 337, Issue 8741, 9 March 1991, Pages 582-583
The Lancet

SHORT REPORTS
Cortisol response to corticotropin and survival in septic shock

https://doi.org/10.1016/0140-6736(91)91641-7Get rights and content

Abstract

Corticotropin stimulation tests were used to assess adrenocortical function in 32 patients with septic shock. 13 patients had a poor cortisol response (rise <250 nmol/l) to corticotropin, all of whom died. However, there were only 6 deaths among the 19 patients with adequate responses (p < 0·001). These results suggest that some patients with septic shock may have relative adrenocortical insufficiency.

References (8)

There are more references available in the full text version of this article.

Cited by (358)

  • Sepsis

    2022, Greene's Infectious Diseases of the Dog and Cat, Fifth Edition
  • Critical illness-related corticosteroid insufficiency in dogs with systemic inflammatory response syndrome: A pilot study in 21 dogs

    2021, Veterinary Journal
    Citation Excerpt :

    In human medicine, although there is currently no consensus regarding the diagnosis of CIRCI, ≤9 μg/dL of Δcortisol, which was defined as the difference of cortisol concentrations between pre and post ACTH-stimulation test, has been proposed as a diagnostic criterion (Marik et al., 2008; Annane et al., 2017). CIRCI has been associated with refractory hypotension and increased mortality (Rothwell et al., 1991; Soni et al., 1995; Annane et al., 2000; Schroeder et al., 2001; Annane et al., 2002). Despite the controversies on the treatment of this syndrome, some studies have suggested that the use of low doses of hydrocortisone significantly improves survival (Schneider, 1991; Bollaert et al., 1998; Briegel et al., 1999; Chawla et al., 1999; Annane et al., 2002; Oppert et al., 2005).

View all citing articles on Scopus
View full text